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Genomics
Coined in 1986 by Tom Roderick, by combining gene and "-omics" (from the Greek word for "all"), this term refers to the scientific study of all the genes and their roles in an organism's structure, growth, health, disease (and/or resistance to disease, etc.). For example, how the (approximately) 3,000 genes in a given strain of bacteria, or the (approximately) 6,000 genes in a given strain of yeast, contribute to the shape, function, and the development of those whole organisms.
Some tools/methods utilized in genomics include:
- STRUCTURAL GENOMICS- The study or discovery of what
particular gene sequences are present, and where they
are located within an organism's DNA.
- GENE FUNCTION ANALYSIS- The determination of which
protein is expressed (i.e., caused to
be "manufactured") by each gene in an organism's
genome. Typically, gene function analysis follows
after structural genomics study.
- FUNCTIONAL GENOMICS- The study or discovery of what
traits/functions are conferred to an organism by given
gene sequence(s).
- CHEMICAL GENETICS- Used to compare two same-
species organisms (one of which has a given gene, or
genes, inactivated by a specific chemical or site
mutation).
- GENE EXPRESSION ANALYSIS- Used to determine product(s)
produced (such as an enzyme or other critical protein)
when a given gene is "switched on", by measuring
fluorescence of individual messenger RNA (mRNA)
molecules (specific to which particular gene
is "switched on" at the time), when that mRNA
hybridizes (with DNA pieces corresponding to proteins
produced/analyzed, that were attached to hybridization
surface on biochip).
- CHROMATIN IMMUNOPRECIPITATION- used to determine all
points on an organism's DNA that a given protein
(e.g., transcription facor) binds to.
One example of genomics was scientists' discovery via gene expression analysis that humans of Asian ancestry are more likely to express the particular mutation of the gene for epidermal growth factor receptor (shown to be present in their DNA via structural genomics) that can result in lung cancer.
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