|
Hutchinson-Gilford Progeria Syndrome
A disease characterized by a mutation in the gene which codes for production of lamin A protein (which thereby results in a buidup of prelamin A at cells' nuclear envelopes) whose symptoms include accelerated osteoporosis, slow growth, loss of muscle strength, cardiovascular disease in children having the disease, etc.
Farnesyltransferase inhibitors administered as a pharmaceutical have been shown in very preliminary research to alleviate the buildup of prelamin A at the cells' nuclear envelopes, and to alleviate some of the symptoms of the disease.
|
